Before taking Premarin

Do not use Premarin if you have:

• a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);
  
  
• abnormal vaginal bleeding that a doctor has not checked;
  
• liver disease; or
  
• any type of breast, uterine, or hormone-dependent cancer.
  

Before using Premarin, tell your doctor if you are allergic to any drugs, or if you have:

• high blood pressure, heart disease, or circulation problems;
  
• a personal or family history of stroke;
  
• endometriosis;
  
• kidney disease;
• asthma;
  
• epilepsy or other seizure disorder;
  
• migraines;
  
• diabetes;
  
• underactive thyroid;
  
• high cholesterol or triglycerides;
  
• high or low levels of calcium in your blood;
  
• porphyria;
  
• systemic lupus erythematosus (SLE);
  
• gallbladder disease; or
  
• if you have had your uterus removed (hysterectomy).
  

Premarin increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using Premarin may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using Premarin.
Long-term Premarin treatment may increase your risk of stroke or blood clots. Talk with your doctor about your individual risks before using Premarin long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
FDA pregnancy category X. This medication can cause birth defects. Do not use Premarin if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Premarin can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby. Do not give this medication to anyone under 18 years old without the advice of a doctor.